Skip to main content
. 2015 Oct 6;5(12):1328–1342. doi: 10.7150/thno.11432

Figure 6.

Figure 6

Role of IL-1β in SLΔppGpp-mediated cancer therapy. (A) Protocols for co-treatment with an IL-1β blocking antibody (left) or recombinant IL-1β (right), plus PBS or SLΔppGpp. (B) CT26 cells were transplanted into mice. Mice then received an intravenous (i.v.) injection of PBS (black rectangles) or SLΔppGpp (black circles). IL-1β depletion: mice received an i.v. injection of anti-IL-1β-specific antibody (IL-1β Ab) 1 day before SLΔppGpp treatment (Day 1). The antibody was then injected twice a week for 2 weeks (open rectangles). Control mice received isotype (IgG) according to the same schedule (black triangles). Treatment with recombinant IL-1β (rIL-1β): mice received an intratumoral (i.t.) injection of rIL-1β on 5 dpi (open triangles), followed by another i.t injection every other day up until 11 dpi. Another group of tumor-bearing mice received four i.t injections of rIL-1β alone (open circles). Data represent the mean ± SD. Results from at least three individual experiments are shown. *P < 0.05, **P < 0.005, and ***P < 0.001 vs. control at Day 12 and vs. SLΔppGpp at Day 18. (C) Photographs of representative animals in each group were taken before (0 dpi) and after treatment (5 and 16 dpi).