Table 1.
Known lncRNA-interacting proteins
| LncRNAs | Proteins | Mode of Action | Function | Reference |
|---|---|---|---|---|
| Firre | hnRNP-U | Nuclear architecture, transcriptional regulation | Embryonic stem cell self-renewal | 21 |
| HOTAIR | Ezh2, Suz12 | Chromatin modification, transcriptional regulation | Cancer metastasis | 28, 51 |
| HOTTIP | WDR5 | Chromatin modification, transcriptional regulation | Hox gene expression | 22 |
| LincRNA-p21 | hnRNP-K | Transcriptional regulation | p53-mediated gene repression | 15 |
| LincRNA-p21 | HuR | Translational control | Gene suppression in HeLa cells | 52 |
| LincRNA-Cox2 | hnRNP-A/B, A1/B1 | Transcriptional regulation | Innate immunity | 31 |
| NEAT1 | SFPQ | Transcriptional regulation | Innate immunity | 34 |
| NeST | WDR5 | Chromatin modification, transcriptional regulation | Innate immunity | 33 |
| RepA | Ezh2 | Transcriptional regulation | XIST induction | 14 |
| RMST | Sox2 | Transcriptional regulation | Neurogenesis | 53 |
| TINCR | Stau1 | RNA stabilization | Epidermal differentiation | 18 |
| THRIL | hnRNP-L | Transcriptional regulation | Innate immunity | 30 |
| TUNA | PTBP1, hnRNP-K, and NCL | Transcriptional regulation | Embryonic stem cell self-renewal and neural differentiation | 17 |
| Lnc-DC | STAT3 | Phosphorylation and transcriptional regulatioin | Innate and Adaptive Immunity | 45 |