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Proposed mechanism for PML/p62 hybrid body formation. PML and p62 bodies, as detected by I-EM (top row), are often found as distinct bodies in close contact (docking). The docking phase is followed by progressive invasion of the p62 body by the PML body (capture) This leads to the formation of an hybrid body with a p62-rich fibrillar core surrounded by a shell of PML (fusion). Further images evoking progressive capture of p62 bodies by PML bodies are displayed in Figure S3.
