Table 1.
Cohort Description
| Variables | Mean ± SD | Value range | Number of observations | |
|---|---|---|---|---|
| Age (years) | 17.3 ± 9.9 | 5–53 | 628 | |
| RBC (1012/L) | 2.3 ± 3.1 | 1.1–2-6.5 | 626 | |
| Hematological indices | Hb (g/dl) | 7.8 ± 1.5 | 3.5–14.5 | 626 |
| MCV(fl) | 84 ± 10.1 | 59–117 | 626 | |
| MCHC (g/dl) | 34 ± 3.7 | 21.5–54.3 | 626 | |
| WBC (109/l) | 14 ± 5.9 | 2.9–49.8 | 626 | |
| Lymphocytes (109/l) | 5.9 ± 2.9 | 1.9–22.6 | 626 | |
| Monocytes (109/l) | 1.5 ± 1.0 | 0.1–11.9 | 626 | |
| Platelets (109/l) | 373 ± 122 | 97–837 | 626 | |
| HbA2 (%) | 3.7 ± 1.8 | 0–9.7 | 626 | |
| HbF (%) | 10.1 ± 8.6 | 0–26.8 | 626 | |
| Clinical events | Vaso-occlusive crisis (No. /year) | 2.9 ± 3.4 | 0–30 | 593 |
| Consultations (No. /year) | 2.8 ± 3.5 | 0–29 | 591 | |
| Hospitalisation (No. /year) | 1.4 ± 2.1 | 0–15 | 591 | |
| Stroke | 4.2% | 25/599 | ||
| 3.7del Alpha-globin gene genotypes | αα/αα | 59.3% | 310/524a | |
| αα/α3.7 | 29.6% | 156/524a | ||
| α3.7/α3.7 | 11.1% | 58/524a | ||
| HBB haplotypes | Benin/Benin | 57% | 307/541a | |
| Benin/Cameroon | 25% | 137/541a | ||
| Benin/atypical | 8% | 45/541a | ||
| Cameroon/Cameroon | 5% | 2/541a |
a
Number of individuals and not alleles.