Figure 1.

Gut sterilization prevents development of colitis in TLR5KO mice receiving α-IL-10R mAb. Age matched male TLR5KO mice (n = 5 ) with or without α-IL-10R mAb were treated with broad antibiotics (ampicillin and neomycin) in drinking water for 4 weeks and then analyzed for development of colitis. (A) Image displays gross pictures of colon. Bar graphs represent: Weights of (B) Ceca, (C) Colon, (D) Spleen, (E) MPO in colonic tissue, and (F) Serum Lcn2. Results are expressed, as mean ± SEM. Image is representative of 2 independent experiments. *p <0.05.