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IL-10R neutralization failed to induce colitis in GF-TLR5KO mice. Age matched male GF-TLR5KO mice (n = 4−5) received α-IL-10R mAb (1.0 mg/mouse, i.p. weekly) up to 4 weeks and then analyzed for development of colitis. (A) Image displays gross picture of colon. Bar graphs represent: Weights of (B) Ceca, (C) Colon, (D) Spleen, (E) MPO in colonic tissue, and (F) Serum Lcn2. Results are expressed, as mean ± SEM.
