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. 2015 Mar 31;12(3):238–247. doi: 10.1080/15476286.2015.1017238

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Figure 3: — Vast numbers of miRNAs redundantly regulate multiple cellular pathways in CHO-SEAP cells. (A) Phenotypic distribution of all impactful miRNAs significantly affecting cell proliferation, protein expression, apoptosis and necrosis. Subdivisions indicate the total number of miRNAs regulating only a single (red), 2 (green, violet and blue) or multiple (orange) cellular processes. (B) Influence of anti-apoptotic (black bars) miRNAs on cell-specific SEAP productivity (red bars). (C) Influence of anti-apoptotic miRNAs on cell proliferation (green bars). (D) Influence of anti-apoptotic miRNAs on necrotic cell death (blue bars). (E) Influence of anti-apoptotic miRNAs on cell proliferation and cell-specific SEAP productivity. Data are presented as mean ± SD for 3 independent transfections. Statistics: One-way ANOVA (* p <0.05; ** p<0.01; *** p<0.001).