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. 2015 Oct 23;9:413. doi: 10.3389/fncel.2015.00413

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Copyright © 2015 Kourdougli, Varpula, Chazal and Rivera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chronic treatment with Y-27632 after Status Epilepticus (SE) exacerbates neuronal cell death during epileptogenesis. (A) Fluorojade B staining revealed no dead neurons in control vehicle- (A1) and Y-27632-treated animals (A2) (n = 3 for control vehicle-treated rats; n = 4 for control Y-27632-treated rats). (B) Experimental paradigm. Six weeks old male rats were subjected to 3 h of pilocarpine-induced SE. From day 1 to day 5 post SE, the rats were i.p. injected with either vehicle or Y-27632. (C) Fluorojade B positive cells (green) showing the dead neurons in pilocarpine vehicle- (C1) and Y-27632-treated animals (C2) in the CA3 region. (D) The histogram shows the quantification of the number of Fluorojade B positive cells (n = 3 for pilocarpine vehicle-treated; n = 4 for pilocarpine Y-27632-treated). Data are mean ± SEM; ***p < 0.001, p values obtained using t test analysis Scale bars = 20 μm.