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. 2015 Oct 23;7:18. doi: 10.3389/fnsyn.2015.00018

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Copyright © 2015 Dieni, Nestel, Sibbe, Frotscher and Hellwig.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Met-enkephalin-IR and brain-derived neurotrophic factor (BDNF) are upregulated in parallel in the hippocampus of Bassoon mutants. BDNF (red)/met-enk (green) co-labeling in coronal hippocampal sections (CA3) from adult wild-type (WT) mice (A,C,E) and Bsn-mutants (B,D,F). Note the concurrent upregulation of (B) BDNF and (D) Met-enk in SL of Bsn-mutants compared to WT (A,C). High resolution view of SL reveals an increased proportion of BDNF- and Met-enk-double-labeled MFBs in (H) Bsn-mutant compared to (G) WT mice. Nuclei are labeled with DAPI (blue). Scale bars: A–F: 100 μm; G,H: 10 μm. Abbreviations: PCL, pyramidal cell layer of CA3; SL, stratum lucidum; SR, stratum radiatum.