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. 2014 Oct 31;11(9):1189–1198. doi: 10.4161/rna.34345

Figure 2.

Figure 2.

MiR-663 upregulation was observed in bystander cells. (A) MiR-663 expression in bystander HeLa cells 12 h after receiving conditioned medium from HeLa cells subjected to 4 Gy X-ray irradiation. (B) 24 h after transfection with miR-663 mimics or inhibitors, yields of 53BP1 foci in bystander HeLa cells cultured for 2 h in medium conditioned by HeLa cells for 24 h after 4 Gy X-ray irradiation. (C) 24 h after transfection with miR-663 mimics or inhibitors, MNF in bystander HeLa cells cultured in medium conditioned by HeLa cells for 24 h after treatment with 4 Gy X-ray irradiation. (D) 24 h after transfection with miR-663 mimics or inhibitors, MNF in bystander HeLa cells co-cultured with HeLa cells exposed to 4 Gy X-rays. Data were obtained from at least three independent experiments, and presented as means ± SE P values between the indicated samples and sham control are also presented.