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Observed rate constants for the reaction between the enzyme–glycine complex and succinyl-CoA.
| Enzyme | k1a (s−1) | k2b (s−1) | k3c (s−1) |
|---|---|---|---|
| wt mALAS2 | 3.8 ± 0.03 | 0.59 ± 0.005 | 0.038 ± 0.001 |
| K221V | 2.7 ± 0.02 | 0.36 ± 0.003 | 0.030 ± 0.001 |
Rate for quinonoid intermediate II formation.
Rate for first step of quinonoid intermediate II decay.
Rate for second step of quinonoid intermediate II decay.
