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. 2015 Oct 23;5:15390. doi: 10.1038/srep15390

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Copyright © 2015, Macmillan Publishers Limited

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Genes up-regulated (UP) in (A) Alzheimer’s, (B) Parkinson’s diseases and (C) Schizophrenia encode proteins that are poorly abundant under normal conditions¹¹,¹², while down-regulated genes (DOWN) show the opposite trend. Genes up-regulated (UP) in (D) Colorectal, (E) Lung and (F) Prostate cancer encode proteins that are highly abundant in normal conditions, while down-regulated genes (DOWN) show the opposite trend. As physiological concentrations of proteins are linked to their physico-chemical properties⁹,¹⁶,¹⁹, our findings reveal information on intrinsic features of disease-associated genes. The p-values are calculated with Kolmogorov-Smirnov test.