Figure 5. Structural disorder is associated with onset of neurodegenerative diseases.

In Frontotemporal Dementia, Alzheimer’s and Parkinson’s diseases, structural disorder is significantly anti-correlated with age of onset (correlation = −0.90; p-value < 10⁻³). A total of 428 mutations and their relative ages of onset grouped with a 2.5 years window have been used for the analysis. Representative genes have been selected to illustrate individual trends (other genes are shown in black): APP, CHMP2B (red), FUS, GRN, LRRK2 (blue), MAPT, PARK2 (yellow), PARK7, PINK1, PSEN1 (gray), PSEN2 (purple), SNCA, TARDBP (pink) and VCP.