Table 4.
Peroxisomal proliferator-activated receptor (PPAR)-related upstream regulators in thyroids exposed to 131I or 211At according to IPA upstream regulator analysis
| Radionuclide | 211At | 131I | |||||||||||
| Time (h) | 1 | 6 | 24 | 168 | 24 | ||||||||
| Injected activity (kBq) | 1.7 | 100 | 1.7 | 7.5 | 0.064 | 0.64 | 1.7 | 14 | 42 | 1.7 | 13 | 130 | 260 |
| Absorbed dose (Gy) | 0.023 | 1.4 | 0.32 | 1.4 | 0.05 | 0.5 | 1.4 | 11 | 32 | 1.8 | 0.85 | 8.5 | 17 |
| Gene | z score | ||||||||||||
| Pirinixic acid | 3.7 | 4.7 | −0.4 | −0.4 | 5.1 | 3.6 | 0.8 | −1.4 | n.s. | 3.5 | 0.9 | 1.5 | 0.2 |
| PPARA | 2.7 | 3.9 | −0.6 | −1.5 | 5.1 | 3.7 | 2.0 | −0.9 | 1.4 | 2.8 | −0.9 | −0.1 | −0.7 |
| Troglitazone | 2.7 | 5.0 | 1.6 | −0.3 | 2.9 | 2.8 | 1.1 | −2.6 | −2.2 | 1.6 | −0.1 | −1.2 | −2.0 |
| Mono-(2-ethylhexyl)phthalate | 2.9 | 5.6 | 0.6 | 0.5 | 5.0 | 3.1 | 1.6 | n.s. | n.s. | 2.4 | 0.9 | 1.6 | 0.0 |
| PPARG | 2.0 | 5.2 | −0.2 | −0.9 | 4.9 | 2.3 | 1.8 | −1.1 | −0.1 | 2.6 | −0.6 | 1.3 | 0.0 |
| PPARGC1A | 2.2 | 4.1 | −0.4 | 1.2 | 4.5 | 3.0 | 0.9 | 0.8 | 0.8 | 2.3 | 0.0 | 1.8 | 0.0 |
| Rosiglitazone | 1.0 | 5.1 | −0.7 | −2.1 | 4.6 | 1.2 | 1.8 | −0.9 | −0.2 | 2.0 | 1.2 | 0.7 | 0.0 |
| PPARD | 3.1 | 3.9 | 1.5 | n.s. | 3.5 | 3.7 | n.s. | −1.3 | n.s. | 2.6 | −0.8 | 0.3 | n.s. |
| GW501516 | 2.6 | 2.8 | 0.8 | 0.8 | 3.1 | 3.0 | 0.0 | 0.0 | 0.0 | 1.8 | −1.2 | −0.3 | 0.0 |
A z score equal to or larger or less than 2 or −2 indicate activated or inhibited upstream regulator, respectively. A z score value between -2 and 2 is considered not statistically significant. n.s. indicates that IPA was not able to predict upstream regulation of that specific upstream regulator for the specific exposure condition