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. 2015 Oct 20;6:8614. doi: 10.1038/ncomms9614

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Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

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The Pfs47 alleles of 516 parasite isolates were genotyped against the 3D7 reference genome (ver. 3). This procedure identified 22 different haplotypes, which are listed in order of decreasing prevalence in our sample collection (Supplementary Tables 1 and 2). The Pfs47 haplotypes of parasites from the core population of Eastern Cambodia (KH-C) and multiple founder populations of Western (WKH), Northern (NKH) and Northeastern (NEKH) Cambodia are indicated. The six ART-resistant isolates we used in our study belong to the WKH-F02, WKH-F04 and WKH-F03 founder populations (*), all of which possess the same Pfs47 haplotype 1 (Supplementary Tables 1 and 2). The three ART-sensitive isolates we used belong to the KH-C/WT population (**) and have the same Pfs47 haplotype 3 (Supplementary Tables 1 and 2). It is noteworthy that Pfs47 haplotype 1 is present in four of five ART-resistant founder populations, whereas all 22 Pfs47 haplotypes are present in ART-sensitive isolates (Supplementary Table 2).