Skip to main content
. 2015 Oct 23;5:15659. doi: 10.1038/srep15659

Figure 2. TIM-3 and PD-1 expression with T-bet and Eomes co-induction of tumor infiltrating CD8+ T cells in mouse CT26 colon tumor model.

Figure 2

CT-26 tumor cells were inoculated subcutaneously in BALB/c mice and were allowed to form solid tumor. Mice were sacrificed on day 28- post tumor inoculation. Splenocytes from naïve non tumor-bearing mice served as controls. (a) Majority of tumor-infiltrating CD8+ T cells express TIM-3. CD3+ cells were analyzed for CD8 and TIM-3 expression. (b) Majority of tumor-infiltrating TIM-3+ CD8+ T cells co-expresses PD-1. (c) Majority of tumor-infiltrating CD8+ T cells are with co-induced of T-bet and Eomes. Data are mean ± SD of at least 3 similar experiments (n = 6; *** = p < 0.0001; p values for Mann-Whitney U test).