Table 3.

Distribution of markers in each of the 4 EMC92-ISS–based risk groups

	EMC92		ISS				del17p		del13q		1q gain		HR.FISH.A
EMC92-ISS	HR	n	1	2	3	n	Positive	n	Positive	n	Positive	n	HR	n
Low	0%	365	100%	0%	0%	365	8%	39	44%	39	34%	154	75%	76
Intermediate-low	0%	231	0%	100%	0%	231	5%	60	37%	60	34%	92	44%	70
Intermediate-high	0%	211	0%	0%	100%	211	8%	66	44%	66	41%	101	55%	84
High	100%	166	30%	32%	39%	166	16%	38	74%	39	76%	90	93%	76

The numbers in the data for which the EMC92-ISS risk classification could be determined. For the classifications based on del13q, 1q gain, and HR.FISH.A, a clear correlation was found to the EMC92-ISS classifications. For instance, 93% of EMC92-ISS high-risk patients are positive for HR.FISH.A compared with 44 to 55% of the intermediate group and 75% of the low group.

HR, the percentage of patients indicated as high-risk according to the specified marker; n, number of patients in the EMC92-ISS–based risk group for which the specified marker was available; positive, the percentage of patients positive for the specified marker.