Figure 7. Corticostriatal plasticity is necessary for the specific refinement of behavioral variability.
(A) Schematic of the adapted training sessions for mutant animals and littermate controls. Animals would remain in the same training session until reaching a stable performance. (B) Distance of the sum of all three consecutive IPIs from the final covert target (∑(3 IPIs) <660 ms, ∼4.5 Hz) in SPN NR1 mutants and littermate controls (C) Spread of the distance between three consecutive IPIs around the final covert target. (D–G) Behavior parameters and variability, measured as the Fano factor, during early and late training sessions in SPN NR1 mutants and littermate controls groups. Bars correspond to mean, with data from individual animals plotted on the background (red: SPN NR1-KO; black: littermate controls).
Figure 7—figure supplement 1. Bootstrapping statistics in the SPN NR1-KO data support the observations from the post hoc planned comparisons.
Histograms depicting the sampled statistic (difference between the means of two groups), after sampling with replacement the original data 100.000 times. Red vertical lines correspond to the 5% confidence intervals. Green vertical line corresponds to the mean of the sampled data. Blue vertical line corresponds to the difference between the original data groups (H0).