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. 2014 Oct 31;93(21):e121. doi: 10.1097/MD.0000000000000121

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© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

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Histological characteristics of lymphoma and sarcoidosis. Spleen (A, B, and D) and bone marrow biopsy (C) of patient 1 showing DLBCL. Microscopic analysis of splenic nodules revealed diffuse large irregular lymphoid cells (A and B, HES ×2 and ×20, respectively). Bone marrow biopsy showed an infiltration of irregular lymphoid cells with the same phenotype as the lymphomatous cells in the spleen (C, Giemsa ×20). CD20 immunostaining confirmed that lymphomatous cells in the spleen were B cells (D, ×10). Mediastinal lymph node biopsy realized 8 month later (E, HES ×2; F and G, HES ×10; H, HES ×20) displayed characteristic features of sarcoid granuloma: noncaseating small granulomatous lesions (stars), consisting of epithelioid cells without evidence of mycobacterial infection. Several giant multinucleated cells are shown on panel G (arrowheads). DLBCL = diffuse large B-cell lymphoma.