FIGURE 2.

Intratumoral cytogenetic heterogeneity of locally advanced rectal cancer prior to radiochemotherapy as evaluated by the cytogenetic profile of the ancestral tumor cell clones grouped according to response to therapy (Dworak grade). (A) 9/17 non-responder cases (G0 and G1) showed other heterogeneous cytogenetic profiles in their ancestral tumor clones, which are not represented here; (B) 5/18 partial responder (G2) cases also showed other cytogenetic profiles in their ancestral tumor clones, which are not represented here.