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Interphase nuclei from a biopsy sample of a patient with locally advanced rectal cancer who achieved complete tumor regression after neoadjuvant therapy. Cell nuclei shows loss of the 1p chromosomal region, as defined by simultaneous hybridization for the Tel1p (green spots), 1p36 (red spots), and 1q25 (blue spots) chromosome 1 regions; altered nuclei only show one copy for the Tel1p and 1p36 probes and 2 copies for the chromosome 1q25 probe.
