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A: miR-143/145-KRAS-RREB1 feedback loop. B: Bioinformatics analysis predicted a TATA-binding protein (TBP) binding site in the promoter region of miR-143/145 (underlined sequence). If the polymorphic location is T, it can bind to the transcriptional factor TBP; otherwise, if the polymorphic location is C, it cannot bind to the TBP.
