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Atypical lymphocytes were confirmed by strongly positive immunohistochemical staining for CD20, EBER, EBNA, and LMP1 but negative staining for CD30 (×60). This confirmed the diagnosis of primary adrenal methotrexate-associated Epstein–Barr virus-positive B-cell lymphoproliferative disorder. EBER = EBV-encoded RNA transcript; EBNA = Epstein–Barr nuclear antigen; LMP1 = latent membrane protein 1; LPD = lymphoproliferative disorder.
