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. 2015 Nov;24(13):1437–1442. doi: 10.1177/0961203315591031

Figure 2.

Figure 2

SMAs 11a and 12b, but not 19o, suppress proteinuria and ANA when administered therapeutically. (a) SMAs 11a, 12b, 19o, and PBS were administered following development of proteinuria (>1 mg/ml; arrow). Data presented are mean proteinuria scores ± SEM where n = 6 mice for all groups, except 19o where n = 2 and bars indicate range. (b) H&E and PAS staining of kidney sections from mice (after 22 weeks) treated with PBS, 11a or 12b at the indicated magnification with digital zoom images of glomeruli incorporating 100 µm scale bars. (c) Representative images of ANA staining of HEp-2 slides using the indicated serum dilutions from PBS-, 11a- or 12b-treated mice with ANA levels in individual mice shown in (d). SMAs: small molecule analogues; ANA: antinuclear antibodies; PBS: phosphate-buffered saline; HEp-2: human epithelial type 2; H&E: haematoxylin and eosin; PAS: periodic acid-Schiff.