Table 5.
E. cloacae STs identified in our study: clonal status, pulsotypes, centres, prevalence, carbapenem MIC and β-lactamases.
| CC (ST)a | PFGE profiles | Centres | Isolates (n) | Median MIC (range; μg/mL) |
β-lactamases (number of isolates)b,c | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Imipenem | Ertapenem | Doripenem | Meropenem | |||||||||
| 42 (101, 104, 108) | 2,8,10,14,17–20 | UH1, UH3, UH4, UH5, GH1, GH2 | 13 | 0.38 | (0.13–1) | 1 | (0.75–4) | 0.125 | (0.047–0.75) | 0.125 | (0.064–0.5) | SHV-12 (n = 1) |
| 74 (74) | 31–33,35,41 | UH2, UH3, UH4, UH5, GH2, | 16 | 0.62 | (0.13–2) | 2 | (0.75–12) | 0.25 | (0.064–1) | 0.44 | (0.064–2) | OXA-48 (n = 9), CTX-M-15 (n = 12) |
| 114 (66,114) | 3,5,40 | UH1, UH3, UH5 | 7 | 0.38 | (0.13–2) | 2 | (1–6) | 0.125 | (0.064–0.38) | 0.19 | (0.125–0.5) | CTX-M-9 (n = 1) CTX-M-15 (n = 3), TEM-24 (n = 1), SHV-12 (n = 1) |
| 133 (93, 103,133) | 15,21,23,38,39 | UH3, UH4, UH5, | 10 | 0.44 | (0.19–16) | 2 | (0.75–32) | 0.125 | (0.16–4) | 0.16 | (0.016–12) | CTX-M-9 (n = 7), SHV-12 (n = 3) |
| 234 (50,176,178) | 24,34,37 | UH2, UH3 | 3 | 0.5 | (0.38–1) | 2 | (0.75–12) | 0.25 | (0.064–0.5) | 0.38 | (0.064–0.5) | CTX-M-9 (n = 1), SHV-12 (n = 1) |
| ST110 | 28,29,30 | UH1, UH4, GH2 | 8 | 0.38 | (0.25–1) | 1.25 | (0.75–3) | 0.125 | (0.064–0.75) | 0.16 | (0.047–0.5) | OXA-48 (n = 1), CTX-M-15 (n = 1), SHV-12 (n = 2) |
| ST179 | ND,26,27 | UH3, GH2 | 4 | 0.5 | (0.5–0.75) | 1 | (0.75–4) | 0.094 | (0.064–0.38) | 0.094 | (0.064–0.75) | OXA-48 (n = 1), CTX-M-15 (n = 1) |
| ST100 | 6,7 | UH4 | 2 | 0.25 | (0.25–0.25) | 1.25 | (1–1.5) | 0.063 | (0.032–0.094) | 0.063 | (0.032–0.094) | – |
| ST175 | 16 | UH1, UH2 | 2 | 1.125 | (0.25–2) | 16.25 | (0.75–32) | 0.47 | (0.19–0.75) | 0.56 | (0.125–1) | SHV-12 (n = 1), DHA-1 (n = 1) |
| ST88,89, 102,173, 174,177, 180,181b | 1,4,9,11–13, 25,36 | UH1, UH4, UH5 | 10 | 0.25 | (0.13–1) | 0.88 | (0.75–32) | 0.1 | (0.047–0.75) | 0.079 | (0.064–2) | CTX-M-15 (n = 1), SHV-12 (n = 2), VIM-1 (n = 1) |
aFor E. cloacae, clonal complex determined according to Izdebski et al. (2014).
bCarbapenemase, extended spectrum β-lactamase, plasmid-mediated cephalosporinase. TEM-1 and TEM-2 have not been mentioned.
cOne isolate in each ST.
ND, Not determined; NT, Non-typeable.