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. 1989 Feb;44(2):116–120. doi: 10.1136/thx.44.2.116

Relation of airway responsiveness to duration of work in a dusty environment.

P Ernst 1, R E Dales 1, F Nunes 1, M R Becklake 1
PMCID: PMC461707  PMID: 2648647

Abstract

Health selection within a workforce has been found in several industries and appears to be more pronounced in dustier occupations. In this study of airway disease among workers exposed to asbestos and man made mineral fibres, 215 of 246 construction insulators 50 years old or less and currently working in the Montreal area were examined. Spirometry was completed successfully in 214 workers without known asbestosis and 207 underwent methacholine bronchoprovocation testing. Airway responsiveness was expressed as PC15, the concentration of methacholine causing a 15% fall in the forced expiratory volume in one second (FEV1). Exposure to asbestos and synthetic mineral fibre dust was estimated from the total hours of work in the trade since first employment. After the effect of age, height, and pack years of smoking had been taken into account, no relation was found between hours of work and any indices obtained from the forced expiratory manoeuvre (FEV1/FVC, MMF). After the effect of airway calibre (FEV1/FVC), age, and pack years of cigarette consumption had been taken into account, airway responsiveness decreased as the total hours of work in the trade increased. These findings suggest that workers with greater levels of airway responsiveness are more sensitive to exposure in a dusty workplace and in consequence are less likely to continue. In studies of workforces a survivor effect of this nature will tend to weaken the relation between lung function abnormality and occupational exposure.

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Selected References

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  1. Bahous J., Cartier A., Ouimet G., Pineau L., Malo J. L. Nonallergic bronchial hyperexcitability in chronic bronchitis. Am Rev Respir Dis. 1984 Feb;129(2):216–220. [PubMed] [Google Scholar]
  2. Broder I., Corey P., Davies G., Hutcheon M., Mintz S., Inouye T., Hyland R., Leznoff A., Thomas P. Longitudinal study of grain elevator and control workers with demonstration of healthy worker effect. J Occup Med. 1985 Dec;27(12):873–880. [PubMed] [Google Scholar]
  3. Broder I., Mintz S., Hutcheon M., Corey P., Silverman F., Davies G., Leznoff A., Peress L., Thomas P. Comparison of respiratory variables in grain elevator workers and civic outside workers of Thunder Bay, Canada. Am Rev Respir Dis. 1979 Feb;119(2):193–203. doi: 10.1164/arrd.1979.119.2.193. [DOI] [PubMed] [Google Scholar]
  4. De Sanctis G. T., Kelly S. M., Saetta M. P., Shiner R. J., Stril J. L., Hakim T. S., Cosio M. G., King M., Desanctis G. T. Hyporesponsiveness to aerosolized but not to infused methacholine in cigarette-smoking dogs. Am Rev Respir Dis. 1987 Feb;135(2):338–344. doi: 10.1164/arrd.1987.135.2.338. [DOI] [PubMed] [Google Scholar]
  5. Du Toit J. I., Woolcock A. J., Salome C. M., Sundrum R., Black J. L. Characteristics of bronchial hyperresponsiveness in smokers with chronic air-flow limitation. Am Rev Respir Dis. 1986 Sep;134(3):498–501. doi: 10.1164/arrd.1986.134.3.498. [DOI] [PubMed] [Google Scholar]
  6. Ernst P., Shapiro S., Dales R. E., Becklake M. R. Determinants of respiratory symptoms in insulation workers exposed to asbestos and synthetic mineral fibres. Br J Ind Med. 1987 Feb;44(2):90–95. doi: 10.1136/oem.44.2.90. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ferris B. G. Epidemiology Standardization Project (American Thoracic Society). Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1–120. [PubMed] [Google Scholar]
  8. Fox A. J., Collier P. F. Low mortality rates in industrial cohort studies due to selection for work and survival in the industry. Br J Prev Soc Med. 1976 Dec;30(4):225–230. doi: 10.1136/jech.30.4.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gerrard J. W., Cockcroft D. W., Mink J. T., Cotton D. J., Poonawala R., Dosman J. A. Increased nonspecific bronchial reactivity in cigarette smokers with normal lung function. Am Rev Respir Dis. 1980 Oct;122(4):577–581. doi: 10.1164/arrd.1980.122.4.577. [DOI] [PubMed] [Google Scholar]
  10. Härkönen H., Nordman H., Korhonen O., Winblad I. Long-term effects of exposure to sulfur dioxide. Lung function four years after a pyrite dust explosion. Am Rev Respir Dis. 1983 Nov;128(5):890–893. doi: 10.1164/arrd.1983.128.5.890. [DOI] [PubMed] [Google Scholar]
  11. Kellie S. E., Attfield M. D., Hankinson J. L., Castellan R. M. Spirometry variability criteria--association with respiratory morbidity and mortality in a cohort of coal miners. Am J Epidemiol. 1987 Mar;125(3):437–444. doi: 10.1093/oxfordjournals.aje.a114549. [DOI] [PubMed] [Google Scholar]
  12. Knudson R. J., Lebowitz M. D., Holberg C. J., Burrows B. Changes in the normal maximal expiratory flow-volume curve with growth and aging. Am Rev Respir Dis. 1983 Jun;127(6):725–734. doi: 10.1164/arrd.1983.127.6.725. [DOI] [PubMed] [Google Scholar]
  13. Koskela R. S., Järvinen E., Korhonen H., Mutanen P. Health selection among metal workers. Scand J Work Environ Health. 1983 Apr;9(2 Spec No):155–161. doi: 10.5271/sjweh.2430. [DOI] [PubMed] [Google Scholar]
  14. Koskela R. S., Luoma K., Hernberg S. Turnover and health selection among foundry workers. Scand J Work Environ Health. 1976;2 (Suppl 1):90–105. doi: 10.5271/sjweh.2828. [DOI] [PubMed] [Google Scholar]
  15. Leech J. A., Ghezzo H., Stevens D., Becklake M. R. Respiratory pressures and function in young adults. Am Rev Respir Dis. 1983 Jul;128(1):17–23. doi: 10.1164/arrd.1983.128.1.17. [DOI] [PubMed] [Google Scholar]
  16. Lutsky I. I., Neuman I. Laboratory animal dander allergy: I. An occupational disease. Ann Allergy. 1975 Oct;35(4):201–205. [PubMed] [Google Scholar]
  17. Malo J. L., Filiatrault S., Martin R. R. Bronchial responsiveness to inhaled methacholine in young asymptomatic smokers. J Appl Physiol Respir Environ Exerc Physiol. 1982 Jun;52(6):1464–1470. doi: 10.1152/jappl.1982.52.6.1464. [DOI] [PubMed] [Google Scholar]
  18. Morgan W. K. Industrial bronchitis. Br J Ind Med. 1978 Nov;35(4):285–291. doi: 10.1136/oem.35.4.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Mullen J. B., Wiggs B. R., Wright J. L., Hogg J. C., Paré P. D. Nonspecific airway reactivity in cigarette smokers. Relationship to airway pathology and baseline lung function. Am Rev Respir Dis. 1986 Jan;133(1):120–125. doi: 10.1164/arrd.1986.133.1.120. [DOI] [PubMed] [Google Scholar]
  20. Mur J. M., Cavelier C. Significance of cross-sectional surveys in occupational epidemiology. Scand J Work Environ Health. 1982;8 (Suppl 1):24–25. [PubMed] [Google Scholar]
  21. Neijens H. J., Hofkamp M., Degenhart H. J., Kerrebijn K. F. Bronchial responsiveness as a function of inhaled histamine and the methods of measurement. Bull Eur Physiopathol Respir. 1982 May-Jun;18(3):427–438. [PubMed] [Google Scholar]
  22. Ramsdale E. H., Morris M. M., Roberts R. S., Hargreave F. E. Bronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness. Thorax. 1984 Dec;39(12):912–918. doi: 10.1136/thx.39.12.912. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Ramsdell J. W., Nachtwey F. J., Moser K. M. Bronchial hyperreactivity in chronic obstructive bronchitis. Am Rev Respir Dis. 1982 Nov;126(5):829–832. doi: 10.1164/arrd.1982.126.5.829. [DOI] [PubMed] [Google Scholar]
  24. Shore S. A., Kariya S. T., Anderson K., Skornik W., Feldman H. A., Pennington J., Godleski J., Drazen J. M. Sulfur-dioxide-induced bronchitis in dogs. Effects on airway responsiveness to inhaled and intravenously administered methacholine. Am Rev Respir Dis. 1987 Apr;135(4):840–847. doi: 10.1164/arrd.1987.135.4.840. [DOI] [PubMed] [Google Scholar]
  25. Tabona M., Chan-Yeung M., Enarson D., MacLean L., Dorken E., Schulzer M. Host factors affecting longitudinal decline in lung spirometry among grain elevator workers. Chest. 1984 Jun;85(6):782–786. doi: 10.1378/chest.85.6.782. [DOI] [PubMed] [Google Scholar]
  26. Tashkin D. P., Clark V. A., Coulson A. H., Bourque L. B., Simmons M., Reems C., Detels R., Rokaw S. Comparison of lung function in young nonsmokers and smokers before and after initiation of the smoking habit. A prospective study. Am Rev Respir Dis. 1983 Jul;128(1):12–16. doi: 10.1164/arrd.1983.128.1.12. [DOI] [PubMed] [Google Scholar]
  27. Taylor R. G., Joyce H., Gross E., Holland F., Pride N. B. Bronchial reactivity to inhaled histamine and annual rate of decline in FEV1 in male smokers and ex-smokers. Thorax. 1985 Jan;40(1):9–16. doi: 10.1136/thx.40.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Yan K., Salome C. M., Woolcock A. J. Prevalence and nature of bronchial hyperresponsiveness in subjects with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1985 Jul;132(1):25–29. doi: 10.1164/arrd.1985.132.1.25. [DOI] [PubMed] [Google Scholar]

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