TABLE 1.
Summary of lipidomic changes in serum and liver for Hint1−/− mice
| Serum | Liver | ||
| ↑a | ↓ | ↑ | ↓ |
| LPC (n = 9)b | LPC (n = 2) | LPC (n = 1) | |
| LPE (n = 5) | LPE (n = 2) | ||
| LPA (n = 4) | PC (n = 12) | PC (n = 10) | PC (n = 3) |
| PE (n = 5) | PE (n = 2) | PE (n = 12) | |
| PE-P (n = 4) | PE-P (n = 1) | PE-P (n = 1) | |
| MG (n = 3) | MG (n = 3) | ||
| DG (n = 1) | DG (n = 1) | DG (n = 17) | |
| SM (n = 7) | SM (n = 3) | ||
| CER (n = 1) | CER (n = 2) | CERc (n = 1) | CER (n = 4) |
| Sulfatide (n = 2) | |||
| 20:4d | 18:2d, 20:4d, 22:5d, 22:6d | ||
| butyrylcarnitine, stearoylcarnitine, | |||
| retinylacetate | retinaldehyde, retinoic acid | ||
LPE, lysophosphatidylethanolamine; MG, monoacylglycerol; PE, phosphatidylethanolamine; PE-P, phosphatidylethanolamine plasmalogen.
↑ and ↓ represent increases and decreases, respectively, in molecules determined by the multivariate data analysis of UPLC-ESI-QTOFMS data. The exact fold changes were not determined, except in cases where quantitation by UPLC-ESI-TQMS or extracted ion chromatograms from the UPLC-ESI-QTOFMS data were performed. Such data appear in Figs. 2, 3, and supplementary Fig. III.
n is the number of molecules of a particular class that were found to be either increased or decreased in the Hint1−/− mice.
Glycosylceramide (see supplementary Table IV).
Fatty acid nomenclature: 18:2, linoleic acid; 20:4, arachidonic acid; 22:5, docosapentaenoic acid; 22:6, docosahexaenoic acid.