TABLE 3.

The effect of UGT1A3, UGT1A9, and UGT2B7 genetic variants on 20-HETE glucuronidation

				20-HETE Glucuronidation (pmol/min/mg)
Gene	Genetic Variation	Genotype	n	Mean ± SD	P
UGT1A3	140T>C	T/T	40	784 ± 230	Reference
		T/C	4	836 ± 315	0.678
		C/C	0	0	—
	31T>C	T/T	27	730 ± 281	Reference
		T/C	15	732 ± 296	0.983
		C/C	2	685	0.845
	133C>T	C/C	38	756 ± 230	Reference
		C/T	5	571 ± 230	0.098
		T/T	1	472	0.231
UGT1A9	−118T9>T10	T9/T9	5	375 ± 135	Reference
		T9/T10	26	696 ± 264	0.014*
		T10/T10	13	929 ± 270	0.001**
	1399C>T	C/C	5	489 ± 338	Reference
		C/T	21	714 ± 305	0.294
		T/T	18	811 ± 257	0.031*
UGT2B7	211G>T	G/G	30	728 ± 304	Reference
		G/T	12	738 ± 326	0.925
		T/T	2	678 ± 106	0.821
	802C>T	C/C	13	874 ± 242	Reference
		C/T	18	702 ± 315	0.111
		T/T	13	619 ± 293	0.023*

Significant difference in 20-HETE glucuronidation rates compared with the wild genotypes is represented by *P < 0.05 and **P < 0.01.