Fig. 1.

TG residuals compared with GRS stratified by lean versus obese status. Significantly differently slope coefficients with 95% CIs are displayed, demonstrating a significant interaction between obesity status and a GRS. The rate of increased TG residuals for an increased predisposition is displayed for obese (broken line) and lean (solid line) individuals. Increased risk in obese individuals corresponds to an increased expression of lipid levels above what would normally be expected. This dimorphic effect was dependent on three SNPs tagging APOA5, glucokinase receptor (GCKR), and LPL, not before observed to have adiposity-dependent dimorphic effects.