Fig. 2.

HDLc residuals compared with GRS stratified by lean versus obese status. Significantly differing slope coefficients with 95% CIs are displayed for obese and lean populations. Lean individuals exhibit a greater response to a larger number of HDLc-raising alleles. The dimorphic effect in HDL is due to SNPs tagging cholesteryl ester transfer protein (CETP), endothelial lipase (LIPG), GalNAc-transferase (GALNT2), and phospholipid transfer protein (PLTP), loci not previously noted to exhibit adiposity-dependent dimorphism.