TABLE 1.
Characteristics of the study sample separated by cohort and by trait under study
| n | Male (%) | Age (years) | BMI (kg/m22) | Risk Score | |
| OBLE | |||||
| TG | |||||
| n | 1,784 | 34.1 | 45.4 ± 0.3 | 31.8 ± 0.3 | −0.198 ± 0.01 |
| Lean | 868 | 39.4 | 44.5 ± 0.5 | 20.3 ± 0.1 | −0.192 ± 0.014 |
| Obese | 916 | 28.9 | 46.4 ± 0.4 | 43.1 ± 0.3 | −0.204 ± 0.013 |
| HDL | |||||
| n | 1,779 | 34.3 | 45.5 ± 0.3 | 31.7 ± 0.3 | 0.007 ± 0.001 |
| Lean | 868 | 39.4 | 44.5 ± 0.5 | 20.3 ± 0.1 | 0.009 ± 0.002 |
| Obese | 911 | 25.1 | 46.4 ± 0.4 | 43.0 ± 0.3 | 0.005 ± 0.002 |
| CAD-C | |||||
| TG | |||||
| n | 2,966 | 49.4 | 75 ± 0.1 | 26.3 ± 0.1 | −0.149 ± 0.006 |
| Lean | 788 | 46.4 | 75.8 ± 0.2 | 21.6 ± 0.1 | −0.142 ± 0.011 |
| Obese | 338 | 37.1 | 73.4 ± 0.2 | 34.6 ± 0.2 | −0.145 ± 0.016 |
| Normal | 1,840 | 55.2 | 74.9 ± 0.1 | 26.8 ± 0.1 | −0.153 ± 0.007 |
| HDL | |||||
| n | 2,937 | 49.3 | 74.9 ± 0.1 | 26.3 ± 0.1 | −0.006 ± 0.001 |
| Lean | 596 | 48.2 | 76.1 ± 0.2 | 21.1 ± 0.1 | −0.006 ± 0.002 |
| Obese | 498 | 32.6 | 73.9 ± 0.2 | 33.4 ± 0.1 | −0.005 ± 0.002 |
| Normal | 1,843 | 55.0 | 74.8 ± 0.1 | 26.1 ± 0.1 | −0.005 ± 0.001 |
| Total | |||||
| TG | |||||
| n | 4,718 | 43.7 | 63.9 ± 0.2 | 28.4 ± 0.1 | −0.167 ± 0.005 |
| Lean | 1,656 | 38.3 | 59.4 ± 0.5 | 20.9 ± 0.1 | −0.168 ± 0.009 |
| Obese | 1,222 | 33.7 | 53.8 ± 0.4 | 40.7 ± 0.2 | −0.188 ± 0.011 |
| Normal | 1,840 | 55.3 | 74.9 ± 0.1 | 26.8 ± 0.1 | −0.153 ± 0.007 |
| HDL | |||||
| n | 4,683 | 43.6 | 63.8 ± 0.2 | 28.3 ± 0.1 | −0.001 ± 0.001 |
| Lean | 1,464 | 36.6 | 57.3 ± 0.5 | 20.6 ± 0.1 | 0.003 ± 0.001 |
| Obese | 1,376 | 35.6 | 56.3 ± 0.4 | 39.5 ± 0.2 | 0.001 ± 0.001 |
| Normal | 1,843 | 55.0 | 74.8 ± 0.1 | 26.1 ± 0.1 | −0.005 ± 0.001 |
Values represent mean ± standard deviation, unless otherwise indicated. Lean: BMI <23 kg/m2 and less than 25th percentile. Obese: BMI >30 kg/m2 for >10 years. Normal: 23 kg/m2 ≤ BMI ≤ 30 kg/m2. Risk score corresponds to the sum of the effect size per risk gene multiplied by the effect size of that risk gene, divided by the total number of risk genes. Data are provided as mean ± standard deviation. See supplementary Table I for further details.