TABLE 3.
Individual loci that exert differing effects in obese versus lean subjects
| Obese | Lean | Interaction | |||||||||||
| Locus | Lead SNP | Allelea | Trait | nb | β (SE)c | P | n | β (SE) | P | n | β (SE) | PInteraction | d |
| LPL | rs12678919 | G | TG | 945 | –0.148 (0.03) | 4.03E–06 | 932 | –0.050 (0.03) | 1.13E–01 | 1,877 | –0.21 (0.06) | 6.99E–04 | 0.01 |
| APOA5 | rs964184 | G | TG | 1,078 | 0.159 (0.03) | 1.31E–07 | 1,282 | 0.14 (0.03) | 1.91E–07 | 2,360 | 0.15 (0.06) | 8.87E–03 | 0.02 |
| GCKR | rs1260326 | T | TG | 1,189 | 0.0932 (0.03) | 1.21E–03 | 1,569 | 0.067 (0.02) | 6.84E–03 | 2,758 | 0.12 (0.05) | 2.82E–02 | 0.03 |
| CETP | rs3764261 | A | HDL | 1,083 | 0.132 (0.03) | 1.67E–06 | 1,238 | 0.189 (0.03) | 3.15E–13 | 2,415 | –0.21 (0.05) | 1.14E–05 | 0.005882 |
| GALNT2 | rs4846914 | G | HDL | 1,212 | –0.065 (0.03) | 1.24E–02 | 1,463 | –0.002 (0.02) | 9.39E–01 | 2,829 | –0.13 (0.05) | 3.03E–03 | 0.011765 |
| LIPG | rs7241918 | G | HDL | 1,061 | –0.004 (0.03) | 8.96E–01 | 1,178 | –0.102 (0.03) | 1.35E–04 | 2,329 | 0.13 (0.05) | 7.00E–03 | 0.017647 |
| PLTP | rs6065906 | C | HDL | 1,184 | –0.034 (0.03) | 2.01E–01 | 1,435 | –0.107 (0.02) | 1.19E–05 | 2,769 | 0.10 (0.04) | 2.08E–02 | 0.023529 |
a
Active allele analyzed.
b
Number of nonmissing individuals with complete information used in analysis.
c
β coefficient for regression; measured in mM (standard error).
d
FDR of 20% displayed. All achieved FDR <20%; APOA5, GALNT2, and LIPG achieved FDR <10%; LPL and CETP achieved FDR <5%.