Figure 4. Clustered rsIL-7 dosing does not enhance T_N reconstitution.

(a) A schematic representation of the clustered rsIL-7 dosing regimen in which 3 weekly s.c. injections (30µg/kg) followed by 2 weeks of no therapy and then 2 repeat cycles of therapy were administered (on days 0, 7, 14, 35, 42, 49, 70, 77 and 84) to 5 adult (10–12 years) and 6 old (>20 years) RM. (b) Analysis of the proliferative fraction and absolute counts of CD4⁺ T_N and CD8⁺ T_N, and (c) CD4⁺ T_M and CD8⁺ T_M in blood after clustered rsIL-7 treatment. Results (mean + SEM) are shown as percentage of Ki-67⁺, change (Δ) from baseline or absolute counts percentage of baseline. Significance of differences in these parameters between age groups was assessed as described in the materials and methods (*p < 0.05 at each time point).