Figure 5. Long-term repeated single dosing with rsIL-7 has transient effects on CD4⁺ and CD8⁺ T_N counts.

(a) A schematic representation of the dosing protocol in which 4 adult (8–13 years) and 7 old (>20 years) RM received 7 s.c. injections (30µg/kg) of rsIL-7 on days 0, 7, 108, 304, 423 and 542. (b) Analysis of the absolute counts and proliferative fraction of CD4⁺ and CD8⁺ T_N in the blood after each dose of rsIL-7. Results (mean + SEM) are shown as percentage of Ki-67⁺, change (Δ) from baseline or absolute counts percentage of baseline. Significance of differences between age groups was assessed as described in the materials and methods (significant p values are shown; NS, non-significant).