Figure 6.

N-ethylglycine (EG) reduces nociceptive behavior in neuropathic pain. (A), Behavioral data in adult mice after induction of neuropathic pain by chronic constriction injury in the left hind paw expressed as 50% withdrawal threshold (in g). EG (200 mg/kg) or saline was applied subcutaneously after mechanical allodynia had developed 3 days after chronic constriction injury. Assessment of mechanical allodynia was performed with von Frey filaments at indicated time points. (B), Thermal hyperalgesia was assessed by means of paw withdrawal thresholds (in seconds) in response to a heat source applied to the left hind paw (Hargreaves method). Data are expressed as mean ± SEM; n = 8 per group; *P < 0.05 vs control group (saline); 2-way repeated-measures analysis of variance and Bonferroni post hoc test.