Table 1.

Combinations of edge weighting methods/data types for which the given interaction type is significantly enriched at the majority of edge cut-offs.

Combinations of edge weighting methods/data types	Interaction types
Found by both correlation and mutual information in both the line cross data and the treatment data.	Affinity Capture-MS Co-crystal Structure Co-fractionation Positive Genetic Synthetic Rescue Two-hybrid
Found by both correlation and mutual information in the line cross data but only by mutual information in the treatment data.	Affinity Capture-Luminescence
Found by both correlation and mutual information in treatment data but only by correlation in line cross data.	Affinity Capture-RNA Reconstituted Complex
Found by both correlation and mutual information in line cross data but none of correlation or mutual information in treatment data.	Biochemical Activity FRET
Found only by correlation in line cross data and only by mutual information in treatment data.	Synthetic Haploinsufficiency
Found by neither correlation nor mutual information in treatment data, but found only by correlation in line cross data.	Co-purification Dosage Lethality Dosage Rescue PCA Protein-RNA
Found by neither correlation nor mutual information in line cross data, but found only by mutual information in treatment data.	Affinity Capture-Western Far Western
Found by neither correlation nor mutual information in neither line cross data nor treatment data.	Co-localization Dosage Growth Defect Phenotypic Enhancement Phenotypic Suppression Protein-peptide Synthetic Growth Defect Synthetic Lethality