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. 2015 Oct 10;23(11):880–892. doi: 10.1089/ars.2014.6070

FIG. 4.

FIG. 4.

Angiotensin-converting enzyme 2 (ACE2) overexpression rescues endothelial function in db/db mice. (A) Summarized data showing en face immunofluorescence staining of ACE2 expression in endothelial cells of intact mouse aortas from db/db mice with adenoviral ACE2 (Ad-ACE2) or vector (Ad-vector) transduction. (B) Relative Ang(1-7) level in the plasma of db/db mice with Ad-ACE2 and Ad-vector transduction. (C) EDRs in aortas and (D) FMD in mesenteric arteries from Ad-ACE2 or Ad-vector cultured db/db mice. Data are mean±SEM of four to six mice. *p<0.05 versus Ad-vector. (E) EDRs and (F) SNP-induced relaxations in db/db mouse aortas following a 48-h exposure to adenovirus. Data are mean±SEM of five to six mice. *p<0.05 versus Ad-GFP.