Table 3.
Red meat challenges in patients with or without IgE specific for galactose-alpha-1, 3-galactose
Group | Time to Symptoms | Urticaria* | Treatment |
Tryptase Elevation | ||
---|---|---|---|---|---|---|
Antihistamine | Epinephrine | Prednisone | ||||
Allergic (n=12] | 2.45-5.00 hr | 10/12‡ | 9/12 | 2/12 | 4/12 | 3/11# |
Controls (n=13) | NR | 0/13$ | 0/13 | 0/13 | 0/13 | 0/13 |
Urticaria was characterized by flushing
Flushing with intestinal spasms was observed in only one of these subjects
Tryptase rises: i) 4.7 to 10.7 ng/mL, ii) 4.2 to 20,1 ng/mL, iii) 6.2 to 183 ng/mL
p<0.001
Data from Commins SP, James H, Stevens W, et al: Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1, 3-galactose. JACI 2014, 134:108-115.