Fig. 5. The effects of Ang-(1-7) on hemorrhage volume in ICH.
A, Representative pictures of hemorrhage volume in different treatment groups. Scale bars: 2 mm. B, Ang II infusion enlarged the hemorrhage volume, while Ang-(1-7) infusion decreased the hemorrhage volume. C, Neurological deficits were scored in ICH mice. Ang II infusion exaggerated the neurological deficits, while Ang-(1-7) infusion alleviated the neurological deficits. A-779 could abolish the protective effects of Ang-(1-7). &&P< 0.01 vs. sham; **P< 0.01 vs. veh; ++P< 0.01 vs. Ang II, ##P< 0.01 vs. Ang II + Ang-(1-7), n=10/group.