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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Vascul Pharmacol. 2015 Aug 8;73:115–123. doi: 10.1016/j.vph.2015.08.007

Fig. 6. The effects of Ang-(1-7) on regulating gene expressions and cytokine levels in cerebral microvessels.

Fig. 6

The protein expression of NFκB (A) in cerebral microvessels was up-regulated by Ang II infusion, while the expression of IκBα (B) was down-regulated. The levels of TNF-α (C), MCP-1 (D) and IL-8 (E) in the cerebral microvessels were increased by Ang II infusion. Ang-(1-7) blocked all these effects of Ang II. A-779 treatment reversed the effects of Ang-(1-7). &P< 0.05, &&P< 0.01 vs. sham; **P< 0.01 vs. veh; +P< 0.05, ++P< 0.01 vs. Ang II, ##P< 0.01 vs. Ang II + Ang-(1-7), n=10/group.