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. Author manuscript; available in PMC: 2015 Oct 23.
Published in final edited form as: Crit Care Med. 2015 Jan;43(1):149–158. doi: 10.1097/CCM.0000000000000624

Figure 8.

Figure 8

Xenon improves locomotor deficits 1 month after injury. CatWalk-XT gait-analysis tests reveals deficits in locomotor speed, base of support and swing speed that are prevented by treatment with 75% xenon for 3 hours duration, starting at 15 minutes after trauma. A) There is a significant reduction in locomotor speed in TBI-injured animals compared to sham-operated controls. Xenon-treated TBI-injured animals are not significantly different to sham-operated controls. B) Base of support (average separation) of the hind paws was increased in the TBI group compared to sham-operated controls or xenon-treated TBI group, but this did not reach significance. C) Cadence was reduced in the TBI group compared to sham-surgery group, but this did not reach significance (p=0.06). D) Analysis of individual limb speed shows a significant reduction in TBI-injured animals in front left, front right and right hind limb speed compared to sham-operated animals. Xenon-treated TBI-injured animals are not significantly different to sham-operated controls. Bars represent mean values of sham (white), TBI-injury (black) and xenon-treated TBI injury groups (grey). The error bars are standard errors (n=9 sham, n=19, TBI, n=19 TBI + xenon). * = p<0.05, ** = p<0.01 compared to sham-operated control.