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A. Schematic of how chromatin with site-specific PTMs (green symbols) is conventionally assembled from protein semi-synthesis and recombinant expression, followed by DNA ligation. B. Illustration of the display of a histone peptide by a PNA targeting vector (red) which recognizes a specific DNA sequence, resulting in the surrogate of native chromatin used in this study. C. Structure of the PNA vector and the modified histone peptides. Aha = (S)- aminoheptanoic acid.
