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. Author manuscript; available in PMC: 2016 May 26.
Published in final edited form as: Angew Chem Int Ed Engl. 2015 Apr 14;54(22):6457–6461. doi: 10.1002/anie.201500085

Figure 2.

Figure 2

PRC2 methyltransferase activity using MNs and PNA-histone peptide constructs. A. PRC2 stimulation with peptides/PNAs containing the H3K27me3 motif. B. PRC2 inhibition with peptides/PNAs that include either the H3 21–37 K27Aha (aminoheptanoic acid residue) or the H3K4me3 motif. Scintillation counts shown are the average of at least three independent replicates, with error bars representing one standard deviation. PRC2 is depicted with the following color scheme: EZH2 (blue), EED (green), AEBP2 (magenta), RbAp46/8 (red), Suz12 (yellow).