Table 1.
Selected characteristics of Florida-born infants with critical congenital heart disease (CCHD) (n=3,603), 1998-2007
| Characteristic | Infants with timely detected CCHD (n=2,778) n (%) |
Infants with late detected CCHD (n=825) n (%) |
Unadjusted prevalence ratio (95% confidence interval) |
|---|---|---|---|
| Maternal / household | |||
|
| |||
| Mother’s age, years | |||
| ≤ 24 | 945 (34.0) | 321 (38.9) | 1.2 (1.0-1.3) |
| 25-34 | 1,338 (48.2) | 376 (45.6) | Reference |
| ≥ 35 | 495 (17.8) | 128 (15.5) | 0.8 (0.7-1.0) |
| Mother’s race / ethnicity | |||
| White, non-Hispanic | 1,495 (53.9) | 470 (57.0) | Reference |
| Black, non-Hispanic | 621 (22.4) | 178 (21.6) | 1.0 (0.8-1.1) |
| Hispanic | 586 (21.1) | 155 (18.8) | 0.9 (0.8-1.1) |
| Asian / Pacific Islander and American Indian / Alaskan |
50 (1.8) | 17 (2.1) | 1.0 (0.6-1.5) |
| Mother’s education | |||
| Less than high school graduate | 564 (20.3) | 177 (21.5) | 1.1 (0.9-1.3) |
| High school graduate or equivalent | 912 (32.8) | 304 (36.9) | 1.2 (1.1-1.4) |
| College or university (some or graduate) | 1,275 (45.9) | 340 (41.2) | Reference |
| Mother’s nativity: foreign-born | 677 (24.4) | 163 (19.8) | 0.8 (0.7-0.9) |
| Principal healthcare payer type on birth hospitalization recorda | |||
| Private | 1,324 (47.7) | 377 (45.7) | Reference |
| Public | 1,360 (49.0) | 409 (49.6) | 1.1 (0.9-1.2) |
| Self-Insured/Uninsured | 94 (3.4) | 39 (4.7) | 1.3 (0.9-1.7) |
| Birth hospital nursery level | |||
| I | 425 (15.3) | 250 (30.3) | 2.1 (1.8-2.4) |
| II | 598 (21.5) | 214 (25.9) | 1.5 (1.3-1.8) |
| III | 1,755 (63.2) | 361 (43.8) | Reference |
|
| |||
| Infant | |||
|
| |||
| Sex, female | 1,195 (43.0) | 361 (43.8) | 1.0 (0.9-1.2) |
| Preterm or very preterm birth (20-36 weeks) | 595 (21.4) | 143 (17.3) | 0.8 (0.7-0.9) |
| Non-cardiac congenital anomaly | 883 (31.8) | 250 (30.3) | 0.9 (0.8-1.1) |
| Plurality, multiple gestation | 54 (1.9) | 9 (1.1) | 0.7 (0.4-1.3) |
| Critical congenital heart disease (CCHD) typeb,c | |||
| Single condition | |||
| Hypoplastic left heart syndrome (HLHS)c | 196 (7.1) | 27 (3.3) | Reference |
| Aortic interruption/atresia/hypoplasia (AI/A) | 70 (2.5) | 26 (3.2) | 2.2 (1.4-3.6) |
| Coarctation/hypoplasia of aortic arch (COA) | 472 (17.0) | 275 (33.3) | 3.0 (2.1-4.4) |
| Double-outlet right ventricle (DORV) | 77 (2.8) | 32 (3.9) | 2.4 (1.5-3.8) |
| Dextro-transposition of the great arteries (d-TGA)c | 234 (8.4) | 26 (3.2) | 0.8 (0.5-1.4) |
| Ebstein anomaly (EA) | 76 (2.7) | 11 (1.3) | 1.0 (0.5-2.0) |
| Pulmonary atresia (PA)c | 74 (2.7) | 22 (2.7) | 1.9 (1.1-3.2) |
| Single ventricle (SV) | 24 (0.9) | 8 (1.0) | 2.1 (1.0-4.1) |
| Truncus arteriosus (TA)c | 69 (2.5) | 32 (3.9) | 2.6 (1.7-4.1) |
| Total anomalous pulmonary venous connection (TAPVC)c |
55 (2.0) | 37 (4.5) | 3.3 (2.2-5.1) |
| Tetralogy of Fallot (TOF)c | 561 (20.2) | 184 (22.3) | 2.0 (1.4-3.0) |
| Tricuspid atresia (TRA)c | 102 (3.7) | 20 (2.4) | 1.4 (0.8-2.3) |
| Multiple conditions | 768 (27.7) | 125 (15.2) | 0.5 (0.4-0.7) |
| Year of birth | |||
| 1998 | 247 (8.9) | 73 (8.9) | 1.1 (0.8-1.5) |
| 1999 | 234 (8.4) | 86 (10.4) | 1.3 (0.9-1.7) |
| 2000 | 268 (9.7) | 77 (9.3) | 1.2 (0.9-1.6) |
| 2001 | 238 (8.6) | 90 (10.9) | 1.4 (1.1-1.9) |
| 2002 | 265 (9.5) | 73 (8.9) | 1.0 (0.8-1.4) |
| 2003 | 276 (9.9) | 77 (9.3) | 1.2 (0.9-1.6) |
| 2004 | 264 (9.5) | 106 (12.9) | 1.4 (1.1-1.9) |
| 2005 | 331 (11.9) | 69 (8.4) | 0.9 (0.6-1.2) |
| 2006 | 322 (11.6) | 82 (9.9) | 0.9 (0.7-1.2) |
| 2007 | 333 (12.0) | 79 (9.6) | Reference |
Bold results indicate p-value <0.05
a
Private insurance included employer-based insurance (including Tricare). Public insurance included Medicare, Medicaid, Veteran’s Administration insurance, and other state and local government health insurance in Florida, such as KidCare.
b
CCHD identified by ICD-9-CM codes: HLHS: 746.7, AI/A: 747.11, 747.22; COA: 747.10; DORV: 745.11; d-TGA: 745.10; EA: 746.2; PA: 746.01; SV: 745.3; TA: 745.0; TAPVC: 747.41; TOF: 745.2; TRA: 746.1.