Table. 1.
Abundant proteins in eyelid amyloid deposits and control tissue
| Specimen 1 | Specimen 2 | Specimen 3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Amyloid deposits | Control tissue | Amyloid deposits | Control tissue | Amyloid deposits | Control tissue | ||||||
| Protein | mol % | Protein | mol % | Protein | mol % | Protein | mol % | Protein | mol % | Protein | mol % |
| Ig kappa chain C region |
58.3 | Ig kappa chain C region |
61.7 | Ig lambda-2 chain C regions |
55.3 | Hemoglobin subunit beta |
15.8 | Ig lambda-2 chain C regions |
52.8 | Hemoglobin subunit beta |
57.7 |
| Apolipo- protein A-IV |
5.5 | Hemoglobin subunit beta |
6.0 | Ig lambda chain V-III region LOI |
6.1 | Hemoglobin subunit alpha |
14.5 | Hemoglobin subunit beta |
11.1 | Hemoglobin subunit alpha |
35.9 |
| Serum amyloid P- component |
4.4 | Collagen alpha-1(I) chain |
3.7 | Hemoglobin subunit beta |
3.1 | Collagen alpha-1(I) chain |
13.3 | Hemoglobin subunit alpha |
5.6 | Hemoglobin subunit delta |
1.9 |
| Collagen alpha-1(I) chain |
3.6 | Dermcidin | 3.4 | Immunoglobulin lambda-like polypeptide 5 |
3.0 | Collagen alpha-2(I) chain |
7.0 | Collagen alpha-1(I) chain |
3.5 | Collagen alpha-1(I) chain |
1.4 |
| Apolipo- protein E |
3.1 | Hemoglobin subunit alpha |
3.0 | Serum amyloid P-component |
2.4 | Histone H4 | 6.1 | Collagen alpha-2(I) chain |
2.3 | Collagen alpha-2(I) chain |
0.7 |
| Vitronectin | 2.7 | Neutrophil defensin 1 |
2.8 | Collagen alpha- 1(I) chain |
2.2 | Vimentin | 5.1 | Apolipo- protein A-IV |
2.2 | Ig lambda-2 chain C regions |
0.4 |
| Apolipo- protein A-I |
2.7 | Apolipo- protein A-IV |
2.7 | Hemoglobin subunit alpha |
2.0 | Collagen alpha-1(III) chain |
4.7 | Apolipo- protein A-I |
2.2 | Hemoglobin subunit gamma-2 |
0.3 |
| Collagen alpha-2(I) chain |
2.1 | Collagen alpha-2(I) chain |
2.6 | Apolipo- protein A-I |
1.8 | Ig lambda chain V-III region LOI |
4.6 | Hemoglobin subunit delta |
1.9 | Hemoglobin subunit gamma-1 |
0.3 |
| Protein S100-A6 |
2.0 | Apolipo- protein E |
1.7 | Ig kappa chain C region |
1.8 | Hemoglobin subunit delta |
3.8 | Collagen alpha-1(III) chain |
1.6 | Collagen alpha-1(III) chain |
0.3 |
| Neutrophil defensin 1 |
2.0 | Collagen alpha-1(III) chain |
1.5 | Collagen alpha- 2(I) chain |
1.6 | Serum albumin |
3.4 | Vimentin | 1.6 | Carbonic anhydrase 1 |
0.1 |
The table depicts the ten most abundant proteins within the amyloid deposits of the eyelid and control eyelid tissue. Results are from specimen 1, 2 and 3 listed according to their molar % values. The molar % values are averages of two technical replicates [34].