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. Author manuscript; available in PMC: 2016 Oct 14.
Published in final edited form as: J Am Chem Soc. 2015 Oct 1;137(40):13167–13175. doi: 10.1021/jacs.5b08754

Figure 1.

Figure 1

Granulocyte colony-stimulating factor (G-CSF). Structure and therapeutic forms of 1, 2, and designed 3. (A) Linear representation of G-CSF (Met0 + 1–174) with disulfide linkages removed for clarity (Cys36–Cys42, Cys64–Cys74). (B) Representation of protein structure and helix directionality.3a (C) Structure of the native O-linked carbohydrates at Thr133 (1) and targeted N-linked glycoform at Asn133 (3).