Skip to main content
. Author manuscript; available in PMC: 2015 Oct 24.
Published in final edited form as: Lancet Neurol. 2010 Jan 8;9(2):149–158. doi: 10.1016/S1474-4422(10)70002-8

Table 2.

Imaging classification relative to final clinical diagnosis: discriminative measures

All patients Symptom duration (years)
Symptom duration, clinical follow-up (years)
≤2 >2 ≤2, ≤2 ≤2, >2 >2, ≤2 >2, >2
Idiopathic Parkinson’s disease

Sensitivity 84% (81/96) 77% (23/30) 88% (58/66) 67% (6/9) 81% (17/21) 50% (4/8) 93% (54/58)
Specificity 97% (69/71) 92% (23/25) 100% (46/46) 92% (12/13) 92% (11/12) 100% (20/20) 100% (26/26)
Positive predictive value 98% (81/83) 92% (23/25) 100% (58/58) 86% (6/7) 94% (17/18) 100% (4/4) 100% (54/54)
Negative predictive value 82% (69/84) 77% (23/30) 85% (46/54) 80% (12/15) 73% (11/15) 83% (20/24) 87% (26/30)

Atypical parkinsonian syndrome

Sensitivity 82% (58/71) 72% (18/25) 87% (40/46) 62% (8/13) 83% (10/12) 80% (16/20) 92% (24/26)
Specificity 98% (94/96) 97% (29/30) 98% (65/66) 89% (8/9) 100% (21/21) 88% (7/8) 100% (58/58)
Positive predictive value 97% (58/60) 95% (18/19) 98% (40/41) 89% (8/9) 100% (10/10) 94% (16/17) 100% (24/24)
Negative predictive value 88% (94/107) 81% (29/36) 92% (65/71) 62% (8/13) 91% (21/23) 64% (7/11) 97% (58/60)

Multiple system atrophy

Sensitivity 85% (29/34) 88% (7/8) 85% (22/26) 67% (2/3) 100% (5/5) 88% (7/8) 83% (15/18)
Specificity 96% (25/26) 91% (10/11) 100% (15/15) 83% (5/6) 100% (5/5) 100% (9/9) 100% (6/6)
Positive predictive value 97% (29/30) 88% (7/8) 100% (22/22) 67% (2/3) 100% (5/5) 100% (7/7) 100% (15/15)
Negative predictive value 83% (25/30) 91% (10/11) 79% (15/19) 83% (5/6) 100% (5/5) 90% (9/10) 67% (6/9)

Progressive supranuclear palsy

Sensitivity 88% (21/24) 90% (9/10) 86% (12/14) 80% (4/5) 100% (5/5) 75% (6/8) 100% (6/6)
Specificity 94% (34/36) 100% (9/9) 93% (25/27) 100% (4/4) 100% (5/5) 78% (7/9) 100% (18/18)
Positive predictive value 91% (21/23) 100% (9/9) 86% (12/14) 100% (4/4) 100% (5/5) 75% (6/8) 100% (6/6)
Negative predictive value 92% (34/37) 90% (9/10) 93% (25/27) 80% (4/5) 100% (5/5) 78% (7/9) 100% (18/18)

Data are % (calculation).