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. Author manuscript; available in PMC: 2015 Oct 24.
Published in final edited form as: Chem Biol. 2015 Apr 23;22(4):527–534. doi: 10.1016/j.chembiol.2015.03.016

Figure 2. Small Molecules Enhance Fluoride Uptake and Toxicity in E. coli.

Figure 2

(A) Reporter activity in E. coli treated with 1 and NaF. Data points are the average of three replicates, and error bars represent standard deviations. Decreases in reporter expression at high sodium fluoride and 1 are due to cell death. See Figure S1 for additional control experiments.

(B) Growth of bacteria cultured in the absence or presence of 1 and increasing concentrations of sodium fluoride following 16 hours of incubation at 37°C. DMSO (~1% [v/v] in the growth medium) was used to solublize and deliver test compounds. Data points are the average of three replicates, and error bars represent standard deviations.