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. Author manuscript; available in PMC: 2015 Oct 24.
Published in final edited form as: Chem Biol. 2015 Apr 23;22(4):527–534. doi: 10.1016/j.chembiol.2015.03.016

Figure 4. Summary of Structure Activity Relationships.

Figure 4

Incorporation of electron-withdrawing groups (EWG) at the meta or para position of either aryl ring results in enhanced activity. Utilization of a thiourea typically has little effect on activity compared to a urea, and likewise the asymmetric incorporation of an additional ring system has little affect. Both amide protons are necessary for activity and might be important for hydrogen bonding (dashed lines).