Table 4.
Individual Diagnostic Performance of Biomarkers to Discriminate Tumor, Non-tumor, and Normal Liver Tissues
| Classifiers in each tissue type | ||||||||
|---|---|---|---|---|---|---|---|---|
| Tumor | Non-Tumor | Normal | ||||||
| Test criteria | SSP6108 (HSP27) |
SSP7711 (keratin I) |
SSP0023 (progesterone receptor) |
SSP0026 (cytochrome b5) |
SSP3102 (cathepsin B) |
SSP8103 (haptoglobin) |
SSP0026 (cytochrome b5) |
SSP8103 (haptoglobin) |
| AUC | 0.820 | 0.697 | 0.720 | 0.783 | 0.801 | 0.724 | 0.733 | 0.950 |
| Cut-off point | 6.298 | 5.675 | 5.630 | 9.190 | 7.176 | 6.697 | 9.171 | 7.735 |
| Sensitivity | 0.782 | 0.764 | 0.667 | 0.778 | 0.852 | 0.736 | 0.800 | 0.900 |
| Specificity | 0.797 | 0.562 | 0.779 | 0.738 | 0.672 | 0.708 | 0.523 | 0.870 |
| False positive rate, FPR | 0.203 | 0.438 | 0.221 | 0.262 | 0.328 | 0.292 | 0.477 | 0.130 |
| False negative rate, FNR | 0.218 | 0.236 | 0.333 | 0.222 | 0.148 | 0.264 | 0.200 | 0.100 |
| Accuracy | 0.790 | 0.663 | 0.723 | 0.756 | 0.756 | 0.563 | 0.546 | 0.958 |
| Youden's Index | 0.579 | 0.326 | 0.446 | 0.516 | 0.524 | 0.444 | 0.323 | 0.770 |
| Positive likelihood ratio, LR+ | 3.852 | 1.744 | 3.018 | 2.970 | 2.598 | 2.521 | 1.677 | 6.923 |
| Negative likelihood ratio, LR− | 0.225 | 0.420 | 0.428 | 0.301 | 0.220 | 0.373 | 0.382 | 0.115 |
| Positive predictive value, PV+ | 0.768 | 0.600 | 0.706 | 0.712 | 0.852 | 0.672 | 0.132 | 0.281 |
| Negative predictive value, PV− | 0.810 | 0.735 | 0.735 | 0.800 | 0.846 | 0.459 | 0.966 | 0.990 |